Haliza Mat Husin \u25cf Franziska Schleger \u25cf Ilena Bauer \u25cf Ellen Fehlert \u25cf \r\nIsabelle Kiefer-Schmidt \u25cf Magdalene Weiss \u25cf Karl Oliver Kagan \u25cf \r\nSara Brucker \u25cf Jan Pauluschke-Fr\u00f6hlich \u25cf Hari Eswaran \u25cf \r\nHans-Ulrich H\u00e4ring \u25cf Andreas Fritsche and Hubert Preissl<\/pre>\n
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Abstract<\/span><\/div>\n
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Objective: Prepregnancy obesity and extensive weight gain can lead to diseases in the offspring later in life. The aim of this study was to evaluate the effect of anthropometric and metabolic factors on the fetal autonomic nervous system (ANS) in uncomplicated pregnancies.<\/p>\n
Methods: A total of 184 pregnant women in the second or third trimester were included, and for 104 women, maternal insulin sensitivity (ISI) was determined. Fetal heart rate (HR) and heart rate variability (HRV) were determined by magnetic recording. Associations of maternal prepregnancy BMI, weight gain, and ISI with fetal HR and HRV were evaluated by ANCOVA, partial correlation, and mediation analysis.<\/p>\n
Results: HR was increased and HRV decreased in fetuses of mothers with overweight or obesity in comparison to normal-weight mothers. Fetal HR was negatively correlated with maternal weight gain. Maternal prepregnancy BMI was positively correlated with fetal high frequency and was negatively correlated with low frequency and low\/high frequency ratio. Maternal ISI showed a negative correlation with fetal HR.<\/p>\n
Conclusions: The results show that the fetal ANS is sensitive to alterations of prepregnancy BMI, weight changes, and glucose metabolism. These findings highlight the importance of the intrauterine environment on the developing ANS and the possible programming of obesity.<\/p>\n
Full Text<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"
Haliza Mat Husin \u25cf Franziska Schleger \u25cf Ilena Bauer \u25cf Ellen Fehlert \u25cf Isabelle Kiefer-Schmidt \u25cf Magdalene Weiss \u25cf Karl Oliver Kagan \u25cf Sara Brucker \u25cf Jan Pauluschke-Fr\u00f6hlich \u25cf Hari Eswaran \u25cf Hans-Ulrich H\u00e4ring \u25cf … Maternal Weight, Weight Gain, and Metabolism are Associated with Changes in Fetal Heart Rate and Variability<\/span> weiterlesen →<\/span><\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[1,141],"tags":[],"translation":{"provider":"WPGlobus","version":"2.10.8","language":"de","enabled_languages":["en","de"],"languages":{"en":{"title":true,"content":true,"excerpt":false},"de":{"title":false,"content":false,"excerpt":false}}},"yoast_head":"\n